Home

Welcome to the lab web page of the Nano-Omic-Bio-Engineering-Lab (NOBEL)! The long-term goal of the NOBEL is to make breakthroughs in medicine and biology that instill hope and inspire others. To accomplish this feat, we develop, optimize and apply innovative technologies such as integrative genomic assays and high-throughput sequencing, micro/nanofabricated devices, genome editing and computational modeling to our primary area of focus, which is skeletal muscle. Skeletal muscle is composed of a constellation of cell types, consumes significant amounts of metabolic energy, grows and adapts its structure and function based on its environment and uniquely repairs and regenerates when damaged. Generating fundamental insights into the basic processes of muscle (development, proliferation and differentiation, migration and fusion, responses to stimuli) could be exploited to prevent dysfunction (muscular dystrophy, aging, and disabilities resulting from severe trauma) as well as enhance rehabilitation and exercise performance (warfighters, athletes). The main research thrusts of the laboratory are in 1) muscle stem cell biology and muscle regeneration (myogenic lineage progression, cellular communication networks, adaptation to stimuli), 2) cellular reprogramming and cell-fate plasticity (transcriptional and epigenetic factors, microenvironment interactions, chromatin memory), 3) regenerative medicine (rehabilitation, cell-based therapies and artificial scaffolds) and 4) micro/nanodevices for interacting with and manipulating single cells and molecules. We have strong collaborative efforts with clinicians and translational scientists to develop and utilize our tools for a broad impact in musculoskeletal regenerative applications.