Welcome to the lab web page of the Nano-Omic-Bio-Engineering-Lab (NOBEL)! Our lab is housed in the BioInterfaces Institute and affiliated with the Cellular and Molecular Biology (CMB) Program and Program in Biomedical Sciences (PIBS). The long-term goal of the NOBEL is to make breakthroughs in medicine. To accomplish this feat, we develop, optimize and apply innovative technologies to our primary area of focus, which is skeletal muscle. Skeletal muscle is the primary organ system that defines our complex movements and to a degree our life and joy (“joy’s soul lies in the doing” – W. Shakespeare). This dynamic tissue is composed of a constellation of cell types, consumes significant amounts of metabolic energy, grows and adapts its structure and function based on its environment and uniquely repairs and regenerates when damaged. Projects in our lab focus on generating fundamental insights into the basic processes of muscle (development, proliferation and differentiation, migration and fusion, responses to stimuli) to prevent dysfunction (muscular dystrophy, aging, and disabilities resulting from severe trauma) as well as enhance rehabilitation and exercise performance (warfighters, athletes). The main research thrusts of the laboratory are in 1) muscle stem cell biology and muscle regeneration (myogenic lineage progression, cellular communication networks, adaptation to stimuli), 2) cellular reprogramming and cell-fate plasticity (transcriptional and epigenetic factors, microenvironment interactions, chromatin memory), 3) regenerative medicine (rehabilitation, cell-based therapies and artificial scaffolds) and 4) micro/nanodevices for interacting with and manipulating single cells and molecules. We have strong collaborative efforts to develop and utilize our tools for a broad impact in musculoskeletal regenerative applications.